CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
PDB
4jxt
X-Ray Diffraction
Homo Sapiens
Title
RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Date
Jan. 1, 2021
Authors
Ni, Z. Xu, C. Guo, X. Hunter, G.O. Kuznetsova, O.V. Tempel, W. Marcon, E. Zhong, G. Guo, H. Kuo, W.H. Li, J. Young, P. Olsen, J.B. Wan, C. Loppnau, P. El Bakkouri, M. Senisterra, G.A. He, H. Huang, H. Sidhu, S.S. Emili, A. Murphy, S. Mosley, A.L. Arrowsmith, C.H. Min, J. Greenblatt, J.F.
Disordered part
Chain
B
UniProt DNA-directed RNA polymerase II subunit RPB1 (P24928)
Region 1788 - 1798
In contact
Chain A
UniProt Regulation of nuclear pre-mRNA domain-containing protein 1A (Q96P16)
Region 2 - 132
Interacting domain
Type Identifier Name Start End
Pfam PF04818 CID domain 8 125
Gene3D G3DSA:1.25.40.90 - 1 137
Shared GO terms
cellular_component GO:0005634 nucleus
cellular_component GO:0005654 nucleoplasm
molecular_function GO:0005515 protein binding
Chain A
UniProt Regulation of nuclear pre-mRNA domain-containing protein 1A (Q96P16)
Region 2 - 132
Interacting domain
Type Identifier Name Start End
Pfam PF04818 CID domain 8 125
Gene3D G3DSA:1.25.40.90 - 1 137
Shared GO terms
cellular_component GO:0005634 nucleus
cellular_component GO:0005654 nucleoplasm
molecular_function GO:0005515 protein binding
Cross references
DisProt
ID Namespace IDPO
DP01284 Structural state disorder
DP01284 Molecular function microfibril binding
DP01284 Molecular function microfibril binding
Related structures
PDB Chain Start End Description
4jxt B 1788 1798 CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
7z1k B 1789 1794 Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5
6ic9 C 1790 1802 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser7
6ic9 D 1791 1800 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser7
6ic8 C 1790 1800 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2
6ic8 D 1791 1800 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2
6q5y E 1792 1801 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser5
6q5y F 1792 1801 Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser5
3d9o Z 1795 1803 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9m Y 1797 1799 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9m Z 1795 1803 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9k Y 1795 1800 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9k Z 1790 1798 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9p Y 1797 1799 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9p Z 1795 1802 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9n Y 1795 1802 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9n Z 1795 1802 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9l Y 1790 1799 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
3d9l Z 1795 1802 Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II
6xkb F 1787 1800 Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD
6xkb G 1787 1800 Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD
6xkb I 1786 1800 Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD
6xkb J 1787 1800 Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD
6xkb K 1786 1800 Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD
9b9l C 1793 1804 RPRD1B C-terminal interacting domain bound to a pThr4 CTD peptide
2lto B 1804 1816 TDRD3 complex
2ghq C 1798 1802 CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
2ghq D 1795 1803 CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
2ght C 1798 1802 CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
2ght D 1796 1803 CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II